Objective of this study was to formulate directly compressible orally disintegrating tablets of tramadol hydrochloride with sufficient mechanical integrity, content uniformity, and acceptable palatability to assist patients of any age group for easy administration. Effect of varying concentrations of different superdisintegrants such as crospovidone, croscarmellose sodium, and sodium starch glycolate on disintegration time was studied. Tablets were evaluated for weight variation, thickness, hardness, friability, drug content, in vitro disintegrating time, wetting time and in vitro drug release. The results of disintegration time and wetting time of tablets prepared using crospovidone was significantly superior compared to other two superdisintegrants evaluated. Release of drug was quick from formulations containing crospovidone (F6) compared to the other orally disintegrating tablet prepared.
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